The fast
acetylator phenotype is more prevalent in certain populations.
快速乙酰化表型在某些人群中更为常见。
Patients with the slow
acetylator genotype may experience increased drug toxicity.
携带慢速乙酰化基因型的患者可能会经历药物毒性增强。
N-acetyltransferase 2 (NAT2) is an important enzyme responsible for the
acetylator activity in humans.
N-乙酰转移酶2(NAT2)是负责人类体内乙酰化活性的一种重要酶。
Genetic polymorphisms affecting the
acetylator status can influence the metabolism of anti-tuberculosis drugs.
影响乙酰化状态的遗传多态性可以改变抗结核药物的代谢过程。
Fast
acetylators tend to process and eliminate certain medications more rapidly than slow
acetylators.
相比慢速乙酰化者,快速乙酰化者倾向于更快地处理和消除某些药物。
This study aimed to identify genetic variations in the
acetylator gene among different ethnic groups.
这项研究旨在识别不同种族群体中乙酰化基因的遗传变异。
The
acetylator phenotype can be determined by administering specific drugs and monitoring their metabolic rate.
通过给予特定药物并监测其代谢率,可以确定个体的乙酰化表型。
Some individuals have a combination of both fast and slow
acetylator alleles, leading to an intermediate phenotype.
一些个体同时携带快速和慢速乙酰化等位基因,导致中间表型。
The identification of a patient's
acetylator status can guide personalized treatment regimens.
确定患者的乙酰化状态有助于指导个性化治疗方案。
The effectiveness of isoniazid therapy varies depending on whether a patient is a fast or slow
acetylator.
异烟肼疗法的效果会因患者是快速还是慢速乙酰化者而有所不同。
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