卡尔尼克辛

Calnexin is a lectin found in the endoplasmic reticulum (ER) of eukaryotic cells, responsible for quality control of newly synthesized proteins.
Calnexin是一种存在于真核细胞内质网中的凝集素，负责新合成蛋白质的质量控制。
The calnexin cycle plays a crucial role in protein folding within the ER, ensuring proper glycosylation before proteins are transported to their final destination.
Calnexin循环在内质网中起着关键作用，确保蛋白质在被运输到最终目的地之前正确糖基化。
Research has shown that calnexin deficiency can lead to misfolded proteins and cellular stress responses, contributing to various diseases like neurodegeneration and cancer.
研究表明，Calnexin缺乏会导致蛋白质折叠错误和细胞应激反应，从而引发神经退行性疾病和癌症等。
In yeast, calnexin is encoded by the YNL298C gene and is a homologue of human calnexin-1.
在酵母中，Calnexin由YNL298C基因编码，是人Calnexin-1的同源物。
Scientists use recombinant calnexin for protein purification, as it selectively binds to misfolded proteins during affinity chromatography.
科学家们使用重组Calnexin进行蛋白质纯化，因为它在亲和色谱过程中特异性地结合到错误折叠的蛋白质上。
Calnexin is involved in the unfolded protein response (UPR), a cellular mechanism activated when proteins fail to fold correctly in the ER.
Calnexin参与未折叠蛋白响应（UPR），这是一种当蛋白质在内质网中无法正确折叠时激活的细胞机制。
The interaction between calnexin and its client proteins is regulated by calcium ions, which modulate the enzyme's activity.
Calnexin与其客户蛋白质之间的相互作用受到钙离子的调控，这些离子影响酶的活性。
Calnexin is a multi-subunit protein complex consisting of four identical polypeptide chains, each with a carbohydrate recognition domain (CRD).
Calnexin是一个多亚基蛋白复合体，由四个相同的多肽链组成，每条链都有一个糖基识别域（CRD）。
The study of calnexin has provided insights into the fundamental mechanisms of protein folding and quality control in the cell.
对Calnexin的研究揭示了细胞内蛋白质折叠和质量控制的基本机制。
Researchers have developed chemical probes targeting calnexin to investigate its function in real-time, offering new avenues for therapeutic intervention.
研究人员已经开发出针对Calnexin的化学探针，用于实时研究其功能，为治疗干预提供了新的途径。