Caveolin-1 is a critical component of caveolae, small flask-shaped invaginations found in the plasma membrane of cells.
濒膜小窝中的关键成分。
Research has shown that
caveolin-1 plays a significant role in regulating cell signaling pathways.
研究表明,
caveolin-1在调控细胞信号通路中起着重要作用。
The absence of
caveolin-1 led to an increased susceptibility to cancer development in mouse models.
在小鼠模型中,
caveolin-1的缺失导致了癌症发展的风险增加。
Caveolin-2, another isoform of
caveolin, is expressed primarily in endothelial cells and is involved in blood vessel formation.
caveolin-2是
caveolin的一种异构体,在内皮细胞中主要表达,参与血管形成。
Studies have implicated
caveolin-1 in the regulation of cholesterol metabolism within cells.
有研究指出
caveolin-1在细胞内胆固醇代谢的调节中起到作用。
Caveolin-1 knockdown in breast cancer cells resulted in decreased cell proliferation and migration.
在乳腺癌细胞中敲除
caveolin-1会导致细胞增殖和迁移能力下降。
Caveolin-1 interacts with various signaling molecules, such as PI3K and Akt, to modulate cellular responses.
caveolin-1与PI3K和Akt等多种信号分子相互作用,调节细胞响应。
Researchers discovered that
caveolin-1 expression levels were inversely proportional to the severity of Alzheimer's disease in patients.
研究发现,
caveolin-1表达水平与阿尔茨海默病患者的病情严重程度呈反比。
Caveolin-1 has been implicated in the development of insulin resistance, a key factor in type 2 diabetes.
caveolin-1被认为与2型糖尿病中的胰岛素抵抗有关。
The modulation of
caveolin-1 activity may hold promise for therapeutic interventions in cardiovascular diseases.
调节
caveolin-1活性可能为心血管疾病治疗提供新的策略。
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