巨自噬

Macroautophagy is a fundamental cellular process that degrades and recycles intracellular components.
宏观自噬是一种基本的细胞过程，负责分解和回收细胞内的成分。
The initiation of macroautophagy requires the formation of a double-membrane vesicle called an autophagosome.
宏量自噬的启动需要形成一个名为自噬体的双层膜囊泡。
Dysregulation of macroautophagy has been implicated in various diseases, such as cancer and neurodegeneration.
宏量自噬的失调与多种疾病，如癌症和神经退行性疾病有关。
Macroautophagy plays a crucial role in maintaining cellular homeostasis under stress conditions.
在压力条件下，宏量自噬在维持细胞稳态中起着关键作用。
Autophagy flux, which measures the rate of macroautophagy, can be monitored using fluorescent reporters.
通过荧光报告器，可以监测宏量自噬流速，即自噬速率。
Induction of macroautophagy is a potential therapeutic strategy for treating obesity and diabetes.
诱导宏量自噬是治疗肥胖和糖尿病的潜在疗法。
The ULK1 complex initiates the formation of the phagophore, a precursor to the macroautophagosome.
ULK1复合体启动了前自噬体（phagophore）的形成，这是宏量自噬体的前身。
Macroautophagy is regulated by a network of signaling pathways, including mTOR and AMPK.
宏量自噬受到包括mTOR和AMPK在内的信号传导途径网络的调控。
Defective macroautophagy has been observed in cells affected by Huntington's disease.
在亨廷顿病受累的细胞中观察到了宏量自噬缺陷。
Understanding the molecular mechanisms of macroautophagy is essential for developing new therapeutic interventions.
理解宏量自噬的分子机制对于开发新的治疗方法至关重要。