穿孔素

Perforin is a protein that plays a crucial role in the immune system's ability to destroy virus-infected and cancerous cells.
穿孔素是一种在免疫系统中起关键作用的蛋白质，它有助于摧毁病毒感染和癌变细胞。
Cytotoxic T cells release perforin which creates pores in the target cell membrane, facilitating the entry of granzymes and ultimately leading to apoptosis.
细胞毒性T细胞释放穿孔素，后者在靶细胞膜上形成孔洞，从而有利于颗粒酶的进入并最终导致细胞凋亡。
Perforin knockout mice models have shown reduced efficiency in eliminating abnormal cells, indicating its importance in immune surveillance.
穿孔素敲除小鼠模型显示出消除异常细胞效率降低的现象，这表明穿孔素在免疫监视中的重要性。
The expression level of perforin can be used as a biomarker for assessing the functional status of natural killer (NK) cells.
穿孔素的表达水平可用于评估自然杀伤细胞（NK细胞）的功能状态。
In some autoimmune diseases, an overproduction of perforin by immune cells can lead to tissue damage and inflammation.
在某些自身免疫疾病中，免疫细胞过量产生穿孔素可能导致组织损伤和炎症。
Researchers are exploring the therapeutic potential of modulating perforin activity in order to enhance or suppress immune responses as needed.
研究人员正在探索调节穿孔素活性的治疗潜力，以便根据需要增强或抑制免疫反应。
Perforin-mediated cytotoxicity is a primary mechanism through which the immune system recognizes and eliminates virally infected or transformed cells.
由穿孔素介导的细胞毒性是免疫系统识别并消除病毒感染或转化细胞的主要机制。
Immunotherapy strategies may involve engineering T cells to express high levels of perforin to improve their capacity to kill tumor cells.
免疫疗法策略可能包括设计表达高水平穿孔素的T细胞以提高其杀死肿瘤细胞的能力。
Perforin is synthesized and stored in granules within cytotoxic T lymphocytes and NK cells, ready for deployment upon encountering a target cell.
穿孔素在细胞毒性T淋巴细胞和NK细胞内的颗粒中合成并储存，随时准备在遇到目标细胞时释放。
Recent studies suggest that genetic variations in the perforin gene may influence susceptibility to certain types of cancer and autoimmune diseases.
最近的研究表明，穿孔素基因的遗传变异可能影响对某些类型癌症和自身免疫疾病的易感性。