The
preclinical stage of drug development involves extensive in vitro and in vivo testing to ensure safety and efficacy.
药物开发的预临床阶段包括大量体外和体内测试，以确保安全性和有效性。
Researchers are currently evaluating the
preclinical potential of a new immunotherapy for cancer treatment.
研究人员正在评估这种新型免疫疗法在癌症治疗中的预临床潜力。
Before entering clinical trials, a vaccine must first go through rigorous
preclinical testing on animals.
疫苗在进入临床试验前，必须在动物身上进行严格的预临床测试。
The
preclinical data looked promising, but further studies are needed to confirm these findings in humans.
预临床数据看起来很有前景，但还需要进一步的研究来验证这些结果在人体上的效果。
A
preclinical study demonstrated that the new compound exhibited significant anti-inflammatory properties.
一项预临床研究表明，新化合物具有显著的抗炎特性。
Preclinical evidence suggests that the stem cell therapy might have regenerative effects on damaged tissue.
预临床证据表明，干细胞疗法可能对受损组织有再生作用。
Scientists are working on refining their
preclinical models to better mimic human diseases.
科学家们正致力于改进他们的预临床模型，使其更好地模拟人类疾病。
The
preclinical results showed no signs of toxicity in the tested animals, which is a positive sign.
预临床结果显示，在测试动物中未发现毒性迹象，这是个积极的信号。
Researchers are analyzing the
preclinical data to determine the optimal dosage and administration route for the drug.
研究人员正在分析预临床数据，以确定药物的最佳剂量和给药途径。
After successful
preclinical trials, the researchers are now moving forward with phase I clinical trials.
经过成功的预临床试验后，研究人员现在正进入I期临床试验阶段。
Preclinical studies have showed the vaccine is safe and effective on animals, the company said.
该公司表示，临床前研究表明，该疫苗对动物安全有效。
"This core technology from us has been proven through extensive preclinical and clinical data.
“我们的这项核心技术已经通过广泛的临床前和临床数据得到了验证。
The R&D center is planned to cover over 25,000 square meters and include new preclinical research laboratory facilities, manufacturing process development labs and a good manufacturing practice pilot plant.
研发中心计划占地25000多平方米，包括新的临床前研究实验室设施、制造工艺开发实验室和良好制造实践中试工厂。
"All preclinical studies of SYZJ001 have been completed, and three patent applications related to the study results have been submitted.
“SYZJ001的所有临床前研究已经完成，与研究结果相关的三项专利申请已经提交。
Insilico Medicine demonstrated the first case of AI identifying a novel target for a major pulmonary disease, generating novel molecules for that novel target, and completing the preclinical experiments required to nominate a preclinical candidate in under 18 months.
Insilico Medicine 展示了首例人工智能识别出针对一种主要肺部疾病的新靶点，为该新靶点生成新分子，并在不到18个月的时间内完成提名临床前候选药物所需的所有临床前实验。
The coalition's total investment in Clover's S-Trimer vaccine candidate will be up to $328 million, including previously announced commitments of $69.5 million, which have funded preclinical studies and Phase 1 clinical trials, preparations for the global pivotal Phase 2/3 efficacy study and initial manufacturing scale-up activities.
该联盟对Clover的S-Trimer疫苗候选产品的总投资将达到3.28亿美元，包括先前宣布的6950万美元承诺资金，这些资金已经用于资助临床前研究和第1期临床试验，以及全球关键性的第2/3期疗效研究的准备工作和初期制造规模扩张活动。
Promising preclinical and preliminary Phase 1 data – which will be published in a peer-reviewed publication in the near future - indicate that S-Trimer is well-tolerated and produces strong neutralizing antibody and Th1-biased cell-mediated immune responses, which merit ongoing evaluation of the vaccine candidate, Clover said in a press release.
Clover公司在一个新闻发布会上表示，即将在一份同行评审的出版物上发表的有希望的临床前和初步1期数据显示，S-Trimer耐受性良好，并能产生强效的中和抗体和Th1偏向的细胞介导免疫反应，这使得该疫苗候选物值得继续评估。
The National Medical Products Administration authorized its phase-1 and phase-2 human trials at the same time that day through a fast-track channel based on solid results from preclinical trial studies.
The NMPA authorized its phase-1 and phase-2 human trials at the same time on that day through a fast-track channel based on solid results from preclinical trial studies.
基于坚实的前期临床试验研究结果，NMPA在当天通过快速通道同时批准了其一期和二期人体试验。
CNBG, Sinopharm's subsidiary for vaccine and biological medicine, is also developing a genetic engineering vaccine against the virus, which is still undergoing preclinical research.
At present, the center has started phase I clinical trials for four hepatitis B molecules of different mechanisms, together with several new mechanism projects in the preclinical stage of research.
The selective small molecule inhibitor BGB-3245 was discovered by BeiGene's scientists and is currently in preclinical development.
Insilico has nominated eight preclinical drug candidates since 2021, which were discovered or designed using its proprietary AI platform in a variety of disease areas, including fibrosis, inflammation and cancer.
"With the preclinical cell and animal experiments conducted in multiple CROs in Shanghai and nearby, we could rapidly iterate our artificial intelligence systems and make rapid progress in pipeline research and development," he said.
Currently in the preclinical stage, the molecule cross-links tumor cells and T cells by targeting a specific tumor-associated antigen and a protein complex and thus leads to potent T cell activation to fight the tumor.
The company has also nominated a preclinical candidate compound for innovative cancer immunotherapy in a collaborative project with Chinese pharmaceutical giant Fosun Pharma.
Translating scientific findings into innovative therapies requires a comprehensive understanding of drug development processes, including research, preclinical studies, drug product manufacturing, regulations and clinical trial designs, which take many years of experience, Wei said.
魏表示，将科学发现转化为创新疗法，需要对药物开发全过程有全面理解，包括研究、前临床试验、药品生产、法规及临床试验设计等环节，而这需要多年的经验积累。
”On April 28, the Ministry of Science and Technology issued a guideline on the emergency research and development of SARS-CoV-2 neutralizing antibody products, widely soliciting from society those with mature preclinical effectiveness, safety research foundation, high industrial conversion rate and ability to quickly enter clinical research.
A preclinical study showed JS016 expressed extremely high specific affinity to the SARS-CoV-2 receptor-binding domain on the spike protein blocking the virus from invading host cells.
""Preclinical studies have shown JS016 has strong neutralizing and blocking ability, as well as prophylactic and treatment effect.
The National Medical Products Administration authorized its phase-1 and phase-2 human trials at the same time on that day through a fast-track channel based on solid results from preclinical trial studies.
Preclinical studies have shown immunity combined with the treatment of Vascular endothelial growth factor receptor can generate a synergistic effect on inhibiting the growth of tumors.
It said that the potential therapy has been validated in preclinical tests in human tissue and animal models of IPF.
"This is the first case where AI identified a novel target and designed a preclinical candidate for a very broad disease indication…and we need to have many enabling AI technologies that help us understand and manipulate human biology in other chronic diseases," said Alex Zhavoronkov, founder and CEO of Insilico Medicine.
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